There's many buts though....like I hope they won't exclusively base it on Vampires. With vampires you'll have it crawling with emogoths
Werewolves would work better still, but would make it very combat-oriented (which isn't necessarily a bad thing, but the great thing about WoD is the mix of action and roleplay imo)
I don't even dare hope for a mage-oriented RPG, though they already destroyed that setting for P&P and it would be very hard to have all these options for creating your own spells in a computergame anyway.
Changeling isn't real WoD anyway, so I guess (and hope) they'll leave them out altogether.
And then there's this whole plethora of options with vampire/werewolf hunters, modern templars, enhanced shady government-agents, self-styled superheroes....it could be so much fun!